Eucalyptol
Identity
| Property | Value |
|---|---|
| Preferred name | Eucalyptol (1,8-Cineole) |
| IUPAC name | 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane |
| CAS number | 470-82-6 |
| PubChem CID | 2758 [^5] |
| Chemical family | Bicyclic Monoterpenoid Ether |
| Molecular formula | C10H18O |
| Molecular mass | 154.25 g/mol |
| Stereochemistry | No chiral centers |
Aroma and sensory character
Fresh, minty, camphoraceous, cooling sensory character.
Occurrence outside cannabis
- Eucalyptus (Eucalyptus globulus)
- Rosemary (Rosmarinus officinalis)
- Tea tree (Melaleuca alternifolia)
- Bay leaves (Laurus nobilis)
Physical properties
| Property | Value |
|---|---|
| Standard boiling point | 176 °C |
| Reference pressure | 101.325 kPa |
| Data source | NIST Chemistry WebBook (SRD 69); mean of 6 determinations [^1] |
Thermal-extraction context
Reported biological activity
Human evidence
A placebo-controlled double-blind trial found that oral cineole (1,8-cineole) improved symptoms and cough frequency in patients with acute bronchitis [^2]. A separate double-blind trial in COPD patients found that oral cineole (200 mg, three times daily) added to standard therapy reduced exacerbations, dyspnea, and improved lung function [^3]. Both studies evaluated oral capsules, not inhalation from a vaporizer.
Animal or laboratory evidence
Peer-reviewed reviews of eucalyptus-oil pharmacology summarize anti-inflammatory, antimicrobial, and respiratory-relief activity attributed largely to 1,8-cineole in animal and cell models 1. The underlying experiments are predominantly preclinical; human data are oral-route clinical trials, not inhaled vaporizer studies.
Traditional or anecdotal claims
Longstanding use in respiratory vapor inhalations and chest rubs.
Cannabis laboratory results
An occasional, usually minor constituent: detected in only 3 of 19 dried-flower cultivars in a Thai GC-MS survey (0.01–0.39% of identified peak area) and below detection in the rest 2. Check Lab Results for detected levels.
Sources
Related pages
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El Shiekh RA, et al. Therapeutic applications of eucalyptus essential oils. Inflammopharmacology. 2024. doi:10.1007/s10787-024-01588-8. PMID 39499358. (Peer-reviewed review.) ↩
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Janta S, et al. Chemical profiling and clustering of various dried cannabis flowers. J Cannabis Res. 2024. doi:10.1186/s42238-024-00252-w. PMID 39639406. ↩
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