Nerolidol
Identity
| Property | Value |
|---|---|
| Preferred name | Nerolidol (trans/cis mixture) |
| IUPAC name | (6E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol (trans); (6Z)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol (cis) |
| CAS number | 7212-44-4 (mixed/unspecified) |
| PubChem CID | 5284507 [^3] |
| Chemical family | Acyclic Sesquiterpenoid |
| Molecular formula | C15H26O |
| Molecular mass | 222.37 g/mol |
| Stereochemistry | Two geometric isomers are distinct identities: trans-nerolidol (CAS 40716-66-3) and cis-nerolidol. CAS 7212-44-4 is commonly used for the mixed/unspecified material; each isomer also has enantiomeric forms |
Aroma and sensory character
Woody, earthy, bark, fresh floral, and citrus-like profile.
Occurrence outside cannabis
- Neroli / Bitter Orange (Citrus aurantium)
- Jasmine (Jasminum species)
- Tea tree (Melaleuca alternifolia)
- Lemongrass (Cymbopogon citratus)
Physical properties
| Property | Value |
|---|---|
| Standard boiling point | 276 °C [^1] |
| Reference pressure | 101.325 kPa |
| Data source | NIST Chemistry WebBook (SRD 69), nerolidol isomer record (549.2 K); reduced-pressure value only under CAS 7212-44-4 |
Thermal-extraction context
Reported biological activity
Human evidence
Reported in pharmaceutical delivery research as a transdermal skin penetration enhancer, based on in vitro studies using human skin tissue; no human clinical evaluation of therapeutic benefit from inhalation was identified for this archive [^2].
Animal or laboratory evidence
Animal and cell assays summarized in a peer-reviewed review report antiparasitic, antifungal, antioxidant, and sedative activity, mostly at non-inhalation doses 1.
Traditional or anecdotal claims
Constituent of traditional woody and floral aromatic tinctures.
Cannabis laboratory results
Usually absent or trace in cannabis flower: the only cultivar above the limit of quantitation in a nine-cultivar profiling study was Black Lime, at <0.1% dry weight 2. Consult Lab Results for batch analyses.
Sources
Related pages
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Chan WK, Tan LTH, Chan KG, Lee LH, Goh BH. Nerolidol: a sesquiterpene alcohol with multi-faceted pharmacological and biological activities. Molecules. 2016;21(5):529. doi:10.3390/molecules21050529. PMID 27136520. (Peer-reviewed review.) ↩
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Zager JJ, Lange I, Srividya N, et al. Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis. Plant Physiol. 2019;180(4):1877–1897. ↩
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