Guaiol
Identity
| Property | Value |
|---|---|
| Preferred name | Guaiol |
| IUPAC name | 2-((3S,8S)-1,2,3,4,5,6,7,8-octahydro-3,8-dimethylazulen-5-yl)propan-2-ol |
| CAS number | 489-86-1 |
| PubChem CID | 227829 [^4] |
| Chemical family | Sesquiterpene Alcohol (guaiane skeleton) |
| Molecular formula | C15H26O |
| Molecular mass | 222.37 g/mol |
| Stereochemistry | Chiral; natural material is (−)-guaiol. NIST lists an epimer as a separate stereoisomer [^1] |
Aroma and sensory character
Woody, balsamic, and sweet guaiacwood character.
Occurrence outside cannabis
- Guaiacwood (Bulnesia sarmientoi)
- Ginger (Zingiber officinale)
- Cypress pine (Callitris species)
- Galangal (Alpinia species)
Physical properties
| Property | Value |
|---|---|
| Measured boiling point | 132–136 °C at 10 Torr (1.33 kPa) [^1] |
| Reference pressure | 1.33 kPa (reduced pressure) |
| Atmospheric-pressure value | Reported in the ≈288–310 °C range in secondary literature; not confirmed by NIST, which lists no atmospheric boiling point for guaiol [^1] |
| Data source | CAS Common Chemistry (132–136 °C @ 10 Torr); NIST WebBook SRD 69, CAS 489-86-1 (no Tboil listed) [^1] |
Thermal-extraction context
Guaiol is a low-volatility sesquiterpene alcohol; atmospheric boiling has not been independently verified, and evaporation from botanical matrix occurs via vapor-pressure-driven loss rather than bulk boiling.
Reported biological activity
Human evidence
No verified controlled human study of inhaled isolated guaiol was identified for this archive [^2].
Animal or laboratory evidence
In vitro studies report RAD51 downregulation and apoptosis induction in non-small-cell lung carcinoma lines at 150 µM (Yang et al. 2016) and antibacterial activity; concentrations are supraphysiological and routes were not inhalation 1.
Traditional or anecdotal claims
Woody aromatics of guaiacwood used in traditional medicine and perfumery.
Cannabis laboratory results
Quantitative flower data are scarce. A high-CBD full-spectrum extract was reported to contain guaiol at ≈10% of its terpene fraction, with γ-curcumene dominant 2. Consult Lab Results for batch-level measurements.
Sources
Related pages
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No publicly reachable primary source is currently cited for the remaining details in this footnote. The details remain approximate or unverified and are not treated as verified archive facts. ↩
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Anil SM, Shalev N, Vinayaka AC, et al. Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages. Sci Rep. 2021;11. doi:10.1038/s41598-021-81049-2. PMID 33446817. ↩
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